Effect of Pitressin
نویسنده
چکیده
POSTERIOR PITUITARY EXTRACT is known to lower the portal venous pressure in animalsl-3 and in man a similar effect has been demonstrated during the control of bleeding from esophageal varices with intravenous pitressin.44 It has been suggested that pitressin lowers portal pressure by increasing splanchnic resistance.7 The present communication concerns the effects of intravenous pitressin on splanchnic hemodynamics in control subjects and in patients with liver disease. The patients included some with cirrhosis in whom the portal vein was patent and some with a surgical portacaval anastomosis. Patients with normal liver structure but with occlusion of the portal vein were also studied. It was thus possible to study the effects of pitressin upon the splanchnic hemodynamics as a whole, and also upon the liver hemodynamics independent of the splanchnic bed in patients in whom portal venous blood was totally diverted from the liver. Methods The patients were divided into three groups. Group 1 consisted of four subjects without liver disease, group 2 consisted of 10 patients with portal cirrhosis in whom splenic venography had confirmed that the portal vein was patent. These patients had varying degrees of portal hypertension. Group 3 consisted of 11 patients with portal cirrhosis and a patent end-to-side portacaval anastomosis confirmed by splenic venography, and two patients in whom splenic venography showed a blocked portal vein and who had a normal liver biopsy.
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Effect of Pitressin on Lipolysis and on Phosphorylase Activity in Rat Adipose Tissue.
VAUGHAN, MARTHA. Effect of Pitressin on lipolysis and on phosphorylase activity in rat adipose tissue. Am. J. Physiol. 207 (5) : 1166-r 16%. rg64.-Pitressin, a mixture of arginine and lysine vasopressins, stimulates the release of glycerol and of free fatty acids from rat epididymal fat pads in vitro. This effect is inhibited by prostaglandin El, which has previously been shown to interfere wit...
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Extrarenal effects of intravenous pitressin in nephrectomized rats.
Using inulin as indicator of the extracellular fluid volume, the effects of Pitressin on the movements of sodium and potassium were studied in the nephrectomized rat together with simultaneously determined direct blood pressure values. Pitressin caused a movement of sodium and water into cells coupled with the extrusion of some potassium during the phase of blood pressure elevation. The beginni...
متن کاملPotentiation of the response to vasopressin (pitressin) by treatment with a combination of chlorpropamide and chlorothiazide in Brattleboro rats with hereditary hypothalamic diabetes insipidus.
1 The effect of a combination of chloropropamide and chlorothiazide in Brattleboro rats with hereditary hypothalamic diabetes insipidus (DI) treated with low doses of vasopressin (Pitressin tannate in oil) was investigated with particular reference to the time course of response from the initiation of treatment. 2 Analysis of the relationship between water intake and body weight indicated no re...
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